LymphedemaV1, France, Analysis, bibRecord, 000582

P‐58 Three cases of pathological dermal deposits associated with internal diseases in dogs (xanthomatosis, calcinosis and amyloidosis)

Identifieur interne : 000582 ( France/Analysis ); précédent : 000581; suivant : 000583

P‐58 Three cases of pathological dermal deposits associated with internal diseases in dogs (xanthomatosis, calcinosis and amyloidosis)

Auteurs : A. Muller [France] ; E. Guaguere [France] ; F. Degorce-Rubiales [France]

Source :

Veterinary Dermatology [ 0959-4493 ] ; 2004-08.

RBID : ISTEX:CA0F53B73350CF8AD3E1D42DDC181B3EAAB9B452

Abstract

Pathological dermal deposits include amyloidosis, calcinosis, mucinosis and xanthomatosis, and are especially rare in dogs. We observed three cases associated with internal diseases. The first case was a cutaneous xanthomatosis associated with pancreatitis in a 10‐year‐old poodle. Abdominal pain, vomiting and hemorrhagic diarrhoea were observed in addition to yellowish papules on the abdomen. Skin biopsies showed a granulomatous inflammation with foamy macrophages. Pancreatitis was confirmed by increased serum levels of amylase and lipase and by ultrasonography. In spite of intensive care, death occurred 12 h after admission. The second case was a cutaneous calcinosis associated with multiple congenital urinary malformations in a 6‐month‐old Brittany spaniel (metastatic calcinosis). Retarded growth and pale mucosae were present with erythematous erosive and ulcerated papules and plaques on the face, abdomen and limbs. Histopathological examination of skin biopsies showed a macrophagic granulomatous reaction around calcium deposits. Blood work revealed anaemia, uraemia, elevated creatinine, hyperphosphatemia and hypercalcaemia. Cystography demonstrated a patent urachus. The dog was euthanized and necropsy revealed bilateral hydronephrosis, nephrocalcinosis, megaureters, a patent urachus and calcified bladder. The third case was a cutaneous and systemic amyloidosis in a 5‐year‐old Siberian husky. Dermal papules, purpuric macules, ulcers and cutaneous fragility were present on the trunk. Histopathological examination of skin biopsies showed multiple dermal accumulations of amorphous eosinophilic material, which was congophilic and gave a characteristic green birefringence under polarized light. The owner refused treatment. The dog died one year later of pulmonary thrombosis and renal failure (renal amyloidosis). Funding: Self‐funded.

Url:

DOI: 10.1111/j.1365-3164.2004.00414_58.x

Affiliations:

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ISTEX:CA0F53B73350CF8AD3E1D42DDC181B3EAAB9B452

Le document en format XML

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<front><div type="abstract" xml:lang="en">Pathological dermal deposits include amyloidosis, calcinosis, mucinosis and xanthomatosis, and are especially rare in dogs. We observed three cases associated with internal diseases. The first case was a cutaneous xanthomatosis associated with pancreatitis in a 10‐year‐old poodle. Abdominal pain, vomiting and hemorrhagic diarrhoea were observed in addition to yellowish papules on the abdomen. Skin biopsies showed a granulomatous inflammation with foamy macrophages. Pancreatitis was confirmed by increased serum levels of amylase and lipase and by ultrasonography. In spite of intensive care, death occurred 12 h after admission. The second case was a cutaneous calcinosis associated with multiple congenital urinary malformations in a 6‐month‐old Brittany spaniel (metastatic calcinosis). Retarded growth and pale mucosae were present with erythematous erosive and ulcerated papules and plaques on the face, abdomen and limbs. Histopathological examination of skin biopsies showed a macrophagic granulomatous reaction around calcium deposits. Blood work revealed anaemia, uraemia, elevated creatinine, hyperphosphatemia and hypercalcaemia. Cystography demonstrated a patent urachus. The dog was euthanized and necropsy revealed bilateral hydronephrosis, nephrocalcinosis, megaureters, a patent urachus and calcified bladder. The third case was a cutaneous and systemic amyloidosis in a 5‐year‐old Siberian husky. Dermal papules, purpuric macules, ulcers and cutaneous fragility were present on the trunk. Histopathological examination of skin biopsies showed multiple dermal accumulations of amorphous eosinophilic material, which was congophilic and gave a characteristic green birefringence under polarized light. The owner refused treatment. The dog died one year later of pulmonary thrombosis and renal failure (renal amyloidosis). Funding: Self‐funded.</div>
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P‐58 Three cases of pathological dermal deposits associated with internal diseases in dogs (xanthomatosis, calcinosis and amyloidosis)

P‐58 Three cases of pathological dermal deposits associated with internal diseases in dogs (xanthomatosis, calcinosis and amyloidosis)

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